Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter
نویسندگان
چکیده
منابع مشابه
Interleukin 18 function requires both interleukin 18 receptor and Na-Cl co-transporter
1. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA 2. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Tsinghua University, Beijing 100005, China 3. Institute for Cardiovascular Prevention (IPEK), Ludwig-M...
متن کاملInterleukin-18 and Interleukin-12 Together Downregulate ATP-Binding Cassette Transporter A1 Expression Through the Interleukin
therosclerotic cardiovascular disease is one of the major causes of death in developed countries. Lipid accumulation, foam cell formation and inflammation are recognized as major features of atherosclerosis.1 Inflammatory cells, mainly macrophages and T cells, produce a wide range of inflammatory cytokines in atherosclerotic lesions, which contributes significantly to the progress of the diseas...
متن کاملInterleukin-18 and interleukin-18 receptor-α expression in allergic asthma.
The inflammatory process in allergic asthma is initiated by Thelper (Th) type-2 cells, which produce a repertoire of cytokines, including interleukin (IL)-4, IL-5, IL-9 and IL-13, which are necessary for immunoglobulin (Ig)E production, airway eosinophilia and goblet cell hyperplasia [1]. IL-18 is another pro-inflammatory cytokine, initially described as interferon (IFN)-c-inducing factor [2]. ...
متن کاملInterleukin 18
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers, and in the context of numerous infectious diseases. This short review will describe the basic biology of IL-18 and thereafte...
متن کاملTargeting interleukin 18 with interleukin 18 binding protein.
A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. However, unlike so...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Medicine
سال: 2015
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3890